Proceedings The 17th Symposium on Trace Nutrients Research
Kyoto, May 25, 2000

NO	Theme	Reporter	Position	P
1	Trace Nutrients and Indexes of Healthy Functions	Hiromichi Okuda	2nd Department of medical Biochemistry, School of Medicine, Ehime University, Ehime 791-0295,Japan	1-
2	Effects of Reconstituted Deep Seawater on Detoxification of Organotin-intoxicated Euglena gracilic Z	Maria Ohta(1),Masumi Watanabe(1),Kaoru Nakamura(2) and Tetsuya Suzuki(1)	(1)Division of marine Life Science, Graduate School of Fisheries Science, Hokkaido University (2)Institute of Chemical Research, Kyoto University	11-
3	Manifestation of tolerance and cell death suppressive factors in the organotin-induced thymus atrophy	Hirofumi Suzuki(1), Yasuko Ohtani(1), Yasuaki Arakawa(1),Takayuki Takeuchi(2), Yukihiro Nakano(2),Harunobu Nakashima(3)	(1)Department of Hygiene & Preventive Medicine, Facalty of Health Science, The University of Shizuoka (2)Research reactor Institute, Kyoto University (3)Ohsaka Prefectural Institute of Public Health	19-
4	The Relationship Between the Cyclic Feed Intake and the Amount of 5-HT in the Brain of Zn Deficient Rats	Atsushi Maruyama, Fumiko Yano	School of Biology - Oriented Science and Technology, Kinki University, Wakayama 649-6493	25-
5	Pharmacokinetic analysis of copper(II)- trien complex in rats - metallokinetic analysis by BCM-EPR method-	Hiroyuki Yasui, Harumi Chino, and Hiromu Sakurai	Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University	25-
6	Induction of Metallothionein by Trivalent Metals	Seiichiro Himeno(1), Rumi Shida(1), Kazuo Kobayashi(2),Tatsuya Hasegawa(3), Yoshiyuki Seko(3), and Nobumasa Imura(1)	(1)Kitasato University, School of Pharmaceutical Sciences (2)Toxicology Research Laboratory, Kissei Pharmaceutical Co.Ltd. (3)Department of Environmental Biochemistry Institute of Environmental Sciences	37-
7	Differences in the cytotoxicity to Ehrlich ascites tumor cells and rat erythrocytes induced by selenium compounds	Yoshihiro Saito, Tsuneko Fujii, Masahiro Honda, Shoko Yoneda, Aya Maeda, Harumi Seo, Masahiko Chikuma	Osaka university of Pharmaceutical Sciences	41-
8	Inhibitory effects of L-arginine treatment on the progression of GeO2-induced tubulointerstitial nephropathy	Hiroyuki Yanagawa and Osamu Wada	Department of Hygiene and Preventive Medicine, Faculty of Medicine, Saitama Medical School	47-
9	Regulation of the Human Cystein Dioxygenase Gene by IL-β	Yasutaka Kajita(1), Yu Hosokawa(1), and Masayuki Totani(2)	(1)Division of Material and Child health Science, National Institute of Health and Nutrition (2)Ibaraki Christian University	53-
10	Hypertrophic effect of dietary phytate on cecum in rats	Noriko Nakahara, Yukako Okazaki and Tetsuyuki Katayama	Laboratory of Nutrition, Faculty of Education, Hiroshima University, Higashi-Hiroshima 739-8523	59-
11	Bone Growth in Adolescent Girls and Its Contributing Factors	Nobuko Hagiwara(1),Tatsuki Inoue(1), Eiko Kitamura (1) and Hideo Koishi(2)	(1)Department of Life, Welfare and Culture, Notre Dame Women's College Kyoto (2)Osaka City University former)	63-
12	Exogenous and Endogenous Oxidation Stress in Liver Nuclei of Fetal and Adult Mice	Riichi Tawa, Akihiro Makayama and Hiromu Sakurai	Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University	71-
13	Morphological Alterations of the Testes in Vitamin B12-Dificient Rats	Megumi Yamagata(1), Toshiaki Watanabe(1), Hiroshi Watanabe(1), Shuhei Ebara(2) and yoshihisa Nakano(2)	(1)Yamagata University School of Medicine, Yamagata 990-8531 (2)Department of Biological Chemistry, University of Osaka Prefectuture, Sakai, Osaka 599-8531	67-
14	Isolation and Chemical Characterization of Antioxidative Substance and Glucans from Fruiting Body of Agaricus blazei	Mariko Kakuta(1), Akiko Tanigawa(1),Hiroe Kikuzaki(2) and Akira Misaki(2)	(1)Konan Women's College (2)Osaka City University	83-
15	Introduction of apoptosic of PC12D cells was analyzed in relation to prooxidant nature of aluminum ion	Ryoko Tsubouchi, Keiko Murakami, Hla Hla Htay,masae Ito, Masataka Yoshino	Department of Biochemistry, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195,Japan	91-
16	Proxidant Action of Polyphenolic Compounds: Stimulation of Low Density by Flavonoid	Keiko Murakami and Masataka Yoshino	Department of Biochemistry, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan	97-
17	The contents of Stachyose in "Murasakizukin", one of Kyoto traditional vegetables.	Kimuko Ohtani, Onkoo Rhee and Takahisa Minamide	Department of Food Sciences and Nutritional Health, Kyoto Prefectual University	103-
18	Effect of Vitamin Ks on the growth of chondrocyte-like ATDC5 cells	Shinjiro Hino, Tohru Matsui and Hideo Yano	Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University	109-
19	Cloning of rCT1p(rat Copper Transport Protein) cDNA and its tissue distribution	Harumi Chino, Makoto Hiromura, Hiroyuki Yasui and Hiromu Sakurai	Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical	115-
20	Relationship between endogenous metals, nitric oxide and lipid peroxidation onindomethacin-induced gastric mucosal damage	Keisuke Kumitomi, Akihiro Nakayama, Hiroyuki Yasui and Hiromu Sakurai	Department of Analytical and Bioinorganic Chemistry Kyoto Pharmaceutical University	121-
21	Characterization of intracellular Copper Trafficking Protein Rah1p of Rat	Takashi Sonoda, Makoto Hiromura and Hiromu Sakurai	Department of Analytical and Bioinorganic Chemistry Kyoto Pharmaceutical University	125-
22	The Effect of Arsenobetaine on Murine Bone Marrow Cells	Teruaki Aakurai, Toshikazu Kaise, Chino Matsubara and Kitao Fujiwara	Laboratory of Environmental Chemistry, School of Life Sciences, Tokyo University of Pharmacy and life Science	129-
23	Alleviation of Cadmium Cytotoxicity by Mangane	Takahiro Yanagiya(1)Nobumasa Imura(2),Syuichi Enomoto(2)Yukihiro Kondo(3) and Seiichiro Himeno(2)	(1)RIKEN(Institute of Physical and Chemical Research) (2)School of Pharmaceutical Sciences, Kitasato University (3)Department of Urology, Nippon Medical School	135-
24	Effects of Chemical Thymus-Lesion on the Brain Functions in the sight of Organotin-induced Thymus Atrophy - Concentration of Elements in the Brain -	Yasuko Ohtani(1),Hirofumi Suzuki(1),Yasuaki Arakawa(1)Takayuki Takeuchi(2),Yukihiro nakano(2),Harunobu Nakashima(3)	(1)Department of Hygiene & Preventive Medicine, Faculty of Health Science, The University of Shizuoka (2)Research Reactor Institute, Kyoto University (3)Osaka Prefectual Institute of Public Health	139-
25	Interaction of Vanadium and copper with serum albumin	Yasuo Kunori, Riichi Tawa and Hiromu Sakurai	Department of Analytical and Bioinorganic Chemistry Kyoto Pharmaceutical University	147-
26	In Vitro Digestibility of Zinc Contained in Oyster	Takayuki Tsujii(1),Masahiro Sakaguchi(1),Ryoji Yasuda(1),Kenji Fukunaga(2),Yoshikazu Matsuda(3),Takao Ohta(3),Yukio Shibata(3),Munehiro Yoshida(3)	(1)Laboratory of Food and Nutritional Sciences, Department of Biotechnology Faculty of Engineering, Kansai University (2)Department of Public Health, Kansai Medical University (3)Central Research Institute, Japan Clinic Co.Ltd.	135-
27	Dose Selenium Status Influence the Ability os Swimming in Mice?	Munehiro Yoshida(3),Misako Suzuki(1),Kenji Fukunaga(2)Kengo Ishihara(3,4),Koichiro Onuki(3)¤Toru Fusiki(3)	(1)Laboratory of Food and Nutritional Sciences, Department of Biotechnology Faculty of Engineering, Kansai University (2)Department of Public Health, kansai University (3)Laboratory of Nutritional Biochemistry, Division of Applied Life Sciences Graduate School of Agriculture, Kyoto University (4)At present: Department of Food and Nutrition, School of Life Studies Sgiyama Jogakuen University	159-
28	NifS-like proteins play a role in biogenesis of elemental sulfur and elemental selenium: Investigation into biosynthesis of iron-sulfur cluster	Shin-ichiro Kato, Hisaaki Mihara, Tatsuo Kurihara, Tohru Yoshimura, Nobuyoshi Esaki	Institute for Chemical Research, Kyoto University	145-
29	Preparation of Monoclonal Antibody against Ginsenoside Rf and Its Enzyme Immunoassay	Cheon-Ho Kim(1),Sang-Mok Lee(2) and Seung-Yeol Nah(3)	(1)Department of Veterinary Medicine, Kangwon National University (2)College of Veterinary Medicine, Kon-Kuk University (3)Department of Physiology, College of Veterinary medicine, Chonnam national University, Korea	169-
30	Effects of Selenium Supplementation of Antoxidative Enzyme Systems of Plasma and Testis in Ethanol-treated Rats	Cheon-Ho, Kim and Gap-soo, Kim	Department of Veterinary Medicine, College of Animal Resources Science, Korean National University, Korean Equine Center	177-
31	Effects of calcium and magnesium intake-tendency on their levels in serum, hairs and nail among patients with general and partial epilepsy	Naomasa Sakamoto(1)Naoya Ohashi(2)Kenji Wakai(3)Tamako Nishiike(1)Hiroshi Iguchi(1)and Yoshio Mosita	(1)Department of Hygiene, Hyogo College of Medicine (2)Department of Neuropsychiatry, Hyogo College of Medicine (3)Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine	183-

SUMMARY 1

NO	17-1
Theme	Trace Nutrients and Indexes of Healthy Functions
Reporter	Hiromichi Okuda
Position	2nd Department of Medical Biochemistry, School of Medicine, Ehime University
Volume	The 17th Symposium on Trace Nutrients Research(1995)
P	P.1-9
Summary	I would like to suggest that trace nutrients may be defined to be food components with a variety of healthy functions in addition to nutritional ones and propose that clues for finding these functions may be in history, society and modern medical science. We have done experiments according to this proposal and succeeded in finding new substances with healthy functions. These are insulin like substances such as adenosine, pyroglutamate, 1ithium,vanadium and minus ion, which stimulate glucose incorporation into fat cells, and anti-cancer substances such as ergosterol and compound X, which inhibit tumor growth without any side effects. We firstly had doubts about the mechanisms of actions of insulin and catecholamines accepted by modern medical science and suggested another mechanisms on these hormones after examining directly biological actions of these hormones without presupposition of signal transductions on the actions of these hormones. The clues for finding the trace nutrients mentioned above were obtained on the way to examining the mechanism of actions of these hormones. Based on these, I suggested the way to find trace nutrients in natural products.

SUMMARY 2

NO	17-2
Theme	Effects of Reconstituted Deep Seawater on Detoxification of Organotin-intoxicated Euglena gracilic Z
Reporter	Maria Ohta(1),Masumi Watanabe(1),Kaoru Nakamura(2) and Tetsuya Suzuki(1)
Position	(1)Division of marine Life Science, Graduate School of Fisheries Science, Hokkaido University (2)Institute of Chemical Research, Kyoto University
Volume	The 17th Symposium on Trace Nutrients Research(1995)
P	P.1-9
Summary	Since deep seawater(DSW)is rich in minerals, contains few microbes, and exhibits physiological functionality, it is being considered as a potential water resource for the21st century and presently used in several areas including functional food, aquaculture, food industries and medicine. Using uncellular organism, Euglena gracilis, as a biomaker, we examined the detoxification effects of reconstituted DSW that was brought about by desalination and subsequent reassemble of major constituents of mineral in raw DSW (referred as RDSW) on biota intoxicated with hazardous chemicals. After removal of NaCl, DSW was sterilized by filtration. E. gracilis Z strain (plant model) was grown heterotrophically under a light/dark regime at 28°C. The Euglena cell motility was impaired, and morphology altered by exposure to the toxicant tributyltin chloride. The cells were then incubated in desalinated deep seawater for 180 min, and restration of cell motility and morphology were estimated by videomicroscopy. Distinct restoration effect in E. gracilis Z was observed after incubation with RDSW. The effects were largely attributed to trace minerals that are involved in the biotransformation system and cell motility. Key words-mineral, reconstituted deep seawater, detoxification, organotin, Euglena gracilis

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